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971.
Shengfang Li Xianli Liu Weidong Huang Wen Li Xianyou Xia Shilin Yan Jianying Yu 《先进技术聚合物》2011,22(12):2439-2447
Magnetic poly(acrylic acid‐acrylamide‐butyl methacrylate) (P(AAB)) nanocomposite hydrogels were prepared and used as adsorbents for removal and separation of cationic dyes from aqueous solution. These magnetic P(AAB) nanocomposite hydrogels were characterized by scanning electron microscopy (SEM) and vibrating sample magnetometer (VSM). It was found that these magnetic P(AAB) nanocomposite hydrogels had magnetic responsive characters. The dynamic swelling, removal, and separation of cationic dye, crystal violet (CV), and basic magenta (BM) by these magnetic nanocomposite hydrogels were studied. The adsorption capacity and isotherm studies of cationic dyes onto magnetic P(AAB) nanocomposite hydrogels have been evaluated. The magnetic P(AAB) nanocomposite hydrogels containing Fe3O4 particles can be easily manipulated in magnetic field for removal and separation of cationic dyes from aqueous solution. Adsorption process agreed very well with the Langmuir and Freundlich models. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
972.
A sensitive, specific and rapid liquid chromatography-mass spectrometry (LC-MS/MS) method has been developed and validated for enantioselective determination of darusentan enantiomers, orally active potent endothelin-A receptor antagonist, in rat plasma. The plasma samples were pretreated by protein precipitation with methanol and baseline chromatographic separation was performed on a Chiralcel OD-RH column with a mobile phase consisting of acetonitrile/water/formic acid (50:50:0.1, v/v/v) at a flow rate of 0.5 mL/min. The detection was accomplished by multiple-reaction monitoring (MRM) scanning via electrospray ionization (ESI) source operating in the negative ionization mode. The calibration curve was linear over the investigated concentration from 0.500 to 2500 ng/mL (r≥0.995) for each enantiomer using 50 μL of rat plasma. The lower limit of quantitation (LLOQ) for each enantiomer was 0.500 ng/mL. The intra- and inter-day precisions were not more than 10.2% and the accuracy was within the range from -5.4 to 6.3% for darusentan enantiomers. No chiral inversion was observed during the plasma preparation, storage and analysis. The method proved adequate for enantioselective pharmacokinetic studies of darusentan enantiomers after oral administration of three different doses of racemic darusentan. 相似文献
973.
The challenging separation of regioisomers and enantiomers of monoacylglycerols (MAGs) of fatty acids has been achieved using a single chiral HPLC column (Chiralpak® IC or Chiralpak® IA) and hexane/2‐propanol eluent mixtures, without previous derivatization of the samples. The efficacy of the method is independent of the chain length and the degree of unsaturation of the fatty acids of the MAG. In addition, the separation method allows monitoring the time course for the loss of enantiomeric purity of the fatty acid‐derived MAGs in polar hydroxylic solvents. 相似文献
974.
A novel chiral selector, clindamycin succinate, was synthesized and first used as a chiral selector in capillary electrophoresis (CE). The chiral resolution ability of this kind of clindamycin derivation was studied by CE using some racemic drugs as model analytes. From the experimental results, it was found that both resolution and selectivity of the selector were dependent on the following parameters: concentration of chiral selectors, pH of the running buffer, temperature of the capillary column, applied voltage and organic modifier used. The results show that the chiral selector possesses high resolution toward some racemic drugs, including ofloxacin, chlorphenamine, tryptophan, propranolol, sotalol and metoprolol. Excellent chiral resolution of these tested drugs was achieved under the optimal conditions of 50 mM clindamycin succinate, 10% MeOH v/v, 50 mM Tris buffer, pH 4.0, at 22 kV and 20 °C within 25 min. 相似文献
975.
976.
Dráb T Kračmerová J Tichá I Hanzlíková E Tichá M Liberda J 《Journal of separation science》2011,34(14):1692-1695
Native polyacrylamide electrophoresis in the presence of two reversible protein anionic stains (Ponceau S and Ponceau 2R) was used to study the oligomeric states of soluble proteins. A mild binding of the used protein stains to nondissociated protein oligomers imposed a charge shift on the proteins resulting into separation of protein species according to their size under physiological conditions. Adsorbed stains could be easily removed after electrophoresis by washing of polyacrylamide gel with buffer and protein complexes could be visualized either by the detection of their enzyme activity or by using a nonspecific protein stain. The specific detection of enzyme activity of glycosidases, lactate dehydrogenase, or phosphatases was shown as an example. 相似文献
977.
Xuezhe Zhao Shengwei Deng Yongmin Huang Honglai Liu Ying Hu 《Frontiers of Chemistry in China》2011,6(3):159-163
The wrinkling of phase-separated binary polymer blend film was studied through combining the Monte Carlo (MC) simulation for
morphologies with the lattice spring model (LSM) for mechanical properties. The information of morphology and structure obtained
by use of MC simulation is input to the LSM composed of a three-dimensional network of springs, which allows us to determine
the wrinkling and the mechanical properties of polymer blend film, such as strain, stress, and Young’s modulus. The simulated
results show that the wrinkling of phase-separated binary polymer blend film is related not only to the structure of morphology,
but also to the disparity in elastic moduli between polymers of blend. Our simulation results provide fundamental insight
into the relationship between morphology, wrinkling, and mechanical properties for phase-separated polymer blend films and
can yield guidelines for formulating blends with the desired mechanical behavior. The wrinkling results also reveal that the
stretching of the phase-separated film can form the micro-template, which has a wide application prospect. 相似文献
978.
The hydrocarbon plus fractions that comprise a significant portion of naturally occurring hydrocarbon fluids create major problems when determining the thermodynamic properties and the volumetric behavior of these fluids by equations of state. These problems arise due to the difficulty of properly characterizing the plus fractions (heavy ends). Proper characterization of the heavier components is important when cubic equations of state and/or solid formation thermodynamic models are used to describe complex phase behavior of reservoir fluids. The effect of heavy fractions characterization on thermodynamic modeling of wax precipitation has been investigated using different models including Won, Pan and proposed models. In order to characterize the plus fraction (heavier part) as a series of pseudocomponents, a probability model that expresses the mole fraction as a continuous function of the molecular weight has been used. The study has been conducted using several mixtures. Two different SCN (single carbon number), C7+ and C10+ were chosen. The Chosen SCN were distributed to multi-components of five, six, and/or ten using continuous function and Gaussian quadrature method. The results showed that the fractioning is required to be able to predict wax precipitation. Distribution of C10+ using a proper distribution function has shown improvement in predictions of WAT and the amount of wax deposited in comparison with the characterization of C7+ using semi-continuous approach. In predicting of WAT and the amount of wax build up the developed model showed superiority over the others. 相似文献
979.
Influence of power-law index on transitional Reynolds numbers for flow over a semi-circular cylinder
In this work, the governing partial differential equations (continuity and Cauchy’s momentum equations) describing the flow of power-law type non-Newtonian fluids across a semi-circular cylinder (oriented with its curved surface in the upstream direction) have been solved numerically. In particular, consideration has been given to the delineation of the critical Reynolds numbers denoting the onset of flow separation from the surface of the cylinder and the onset of the laminar vortex shedding regime. This information is germane to establish the scaling of the macroscopic characteristics like drag coefficient and Strouhal number on the governing parameters, namely, Reynolds number and power-law index. The present results clearly suggest that the transitional Reynolds numbers show a strong dependence on the type (shear-thinning and shear-thickening) of fluid behavior as well as on the severity of the shear-dependence of the viscosity. With reference to the behavior seen in Newtonian fluids, the flow remains not only attached to the surface up to higher Reynolds numbers, but shear-thinning behavior also delays the onset of the laminar vortex shedding regime. As expected, shear-thickening fluids, of course, display the opposite characteristics. 相似文献
980.
开集条件是分形几何的一个重要概念,弱分离条件(WSC)在研究有重叠的迭代函数系统(IFS)中扮演着重要角色.本文考虑满足弱分离条件的自共形迭代函数系统,并给出确定其不变集的Hausdorff维数的一种方式. 相似文献